Features And Benefits
- Products with USP Class VI certification Used
- For use in adherent cell culture applications.
- Personalized therapy for cell adhesion
- Using automated recipe-based perfusion processing for cell harvesting
- Utilization of autologous stem cells in cell and gene therapy applications requires special attention.
- Single-use sensors that have been pre-sterilized and pre-calibrated (for ease of handling and validations)
The workstation of the CellBRx® 1L system manages up to 8 disposable bioreactors, providing automated bench-top processing and assessment of several cell culture runs and studies.
- Completely closed-loop pH and DO control with separate O2 and CO2 controls for each culture vessel
- Automated liquid handling platform for base addition, feeds, and perfusion run setup
- A disposable culture vessel with a simple installation that enables aseptic operation in compliance with cGMP
The approach makes it possible to quickly assess several bioreactor cultures at the microscale, enhancing production while making significant labor and material cost savings.
The CellBRx® 1L system uses practical disposable micro bioreactors that are managed by an automated workstation to imitate the properties of large-scale DBR technology-based bioreactors at the microscale (1L). The workstation module offers automated pH monitoring, enhancing pH control and culture performance during initial bioreactor vessel pH sensor calibration and subsequent in-process re-calibration. Bioprocess engineering entails the maintenance and growth of many cells and microorganisms in a controlled environment so that they can create the needed compounds.
CellBRx® 1L System Offers You:
- An improved method for choosing cell lines and developing perfusion processes that closely resemble the environment found in bigger bioreactors.
- Adopting Quality by Design (QbD) concepts for Perfusion bioprocessing in a straightforward manner
- Significantly lower experiment costs
- Minimal operator setup and clean-up times for more experiments
The CellBRx® 1L System offers a distinct advantage over other bioreactor systems in its capacity to maintain the cells in a support matrix during culture while imparting low shear stress and gentle mixing to the cells thanks to the most cutting-edge and effective DBR technology. As a result, the CellBRx® 1L Systems are the ideal cell processing tool for Autologous stem cell therapy providers. The DBR technology allows comprehensive and effective cell harvesting by using conventional cell detachment processes and methods (such as Trypsinization) while also allowing the huge surface area of fibrous cell carriers for cell attachment and proliferation.
Applications include:
- Optimization Of Perfusion-Based Processes
- Selection Of Cell Line
- The Creation Of Perfusion Media
- Approach To Media Feeds
- Studies From QbD And DoE
- Temporary Infection
- Stem Cell Culture: A Form Of Cell Therapy
- Engineering Tissues On A Microscale
- Personalized Medicine Development
Equivalent units of conventional technologies (Surface area comparison)
Equivalent units of conventional technologies (Surface area comparison)
For more information on CellBRx® 1L system please contact us