Introducing CellBRx®-IST: Revolutionizing Viral Vector & Vaccine Manufacturing
OmniBRx Biotechnologies proudly presents a groundbreaking innovation in biopharmaceutical manufacturing – CellBRx®-IST, the world’s first Integrated, Automated, and Closed-loop system for manufacturing Viral Vectors and Vaccines. This cutting-edge technology is set to redefine the industry by addressing traditional challenges and revolutionizing the production process.
The Challenge: Traditional Bioreactor Technologies
Historically, adherent cells like VERO and HEK-293 have been cultivated on 2-D and 3-D surfaces, using roller bottles and fixed bed/packed bed bioreactors. These methods, while effective, encountered several limitations:
- Process Control Issues: Controlling the growth and maintenance of cells in traditional systems has been complex and labor-intensive.
- Footprint & Labor: These methods require significant space and manpower for operation.
- Inconsistent Performance: Achieving consistent results was often a challenge, impacting product quality and efficiency.
The Solution: SeedBRx with Dynamic Bed Reactor (DBR) Technology
To address these challenges, OmniBRx Biotechnologies has developed the proprietary “SeedBRx,” featuring the revolutionary Dynamic Bed Reactor (DBR) technology. SeedBRx represents a single-use bioreactor that streamlines the cultivation process, offering a multitude of benefits.
Introducing CellBRx®-IST: Integrated Seed Train
Our Integrated Seed Train (IST) is a game-changer, integrating and automating a series of variable-scale bioreactors for seed generation. This groundbreaking technology enables higher cell recovery from the SeedBRx matrix at each scale. Different SeedBRx sizes (1L, 5L, and 10L) are linked in series, producing a sufficient cell quantity for large-scale bioreactors like the CellBRx 50L.
Key Features:
- Pre-Sterilized & Contamination Prevention: Our system incorporates pre-sterilized, inter-connected devices, Significantly reducing the risk of contamination with fully closed-loop systems.
- Robust Automation: Achieve robust process controls with end-to-end automation, minimizing human intervention and errors.
- Compact Footprint: CellBRx®-IST boasts a table-top design, minimizing facility footprint while maximizing efficiency.
- Consistency & Cost Efficiency: Benefit from unparalleled process consistency and reduce upstream costs by up to 90%, decreasing facility requirements, labor, and media consumption.
- High Cell Recovery: CellBRx®-IST consistently delivers more than 85% cell recovery for VERO and more than 92% for HEK-293 in 1L, 5L, and 10L SeedBRx bioreactors.
- Cell Viability & Growth: Achieve consistent cell viability of over 90% and seamless cell growth and recovery when transitioning to larger bioreactors.
- GAMP-5 Compliant IST Controller: Our GAMP-5 compliant IST controller generates invaluable process data for Process Analytical Technology (PAT), enhancing product quality, cost-efficiency, safety, and consistency.