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CellBRx® Bioreactors: Spearheading OmniBRx Biotechnologies’ Single-Use Revolution

The CellBRx® Bioreactors are a development for producers of single-use bioreactors. They are the first completely integrated, perfusion-powered, high-cell-density bioreactors in existence. These bioreactors, which have been painstakingly designed to optimize adherent cell culture procedures, effortlessly combine the advantages of single-use technologies with the superiority of dynamic-bed reactor technology. This small, user-friendly system ushers in a new age for rigid-wall single-use bioreactors. It is designed for rapid deployment. These matrix discs, crafted from medical-grade, non-woven polyester microfibers (with USP Class VI and ISO 10993 certifications), offer an astounding surface area of up to 1500 m2 within a 200L bioreactor system. To put it in perspective, this surface area equates to that of 17,647 Roller Bottles (each with an area of 850 cm2).

A breakthrough in rigid wall-stirred tank single-use bioreactors, the CellBRx®bioreactor is furnished with pre-packed and specially-treated microcarriers inside a supporting matrix. This ground-breaking method eliminates the need for delicate and time-consuming manual operations, creating a streamlined procedure, shorter processing time, and increased cell culture resilience. CellBRx® bioreactors can be inoculated even at low cell densities as cells adhere, flourish, and become embedded within the dynamic-bed support matrix.

CellBRx® Bioreactors are a type of bioreactor that is used to produce cell culture-based vaccines. Instead of using conventional techniques, these bioreactors are intended to offer a more effective and affordable approach to making vaccinations. The development and productivity of cells are improved using a technique known as dynamic bed rotation (DBR). DBR rotates the cell culture medium inside the bioreactor, which benefits the cells by giving them a more uniform environment and enhancing the flow of nutrients and oxygen.

This has been shown to increase the yield of vaccines by up to 50% compared to traditional methods. Additionally, more scalable CellBRx® Bioreactors are the best choice for mass-producing vaccinations.

Significant cost reductions are achieved through streamlined processes in CellBRx®

bioreactors. The use of magnetically driven disc rotations with curved vanes in dynamic bed reactors ensures uniform nutrition distribution and reduces mixing time. Our dual integrated aeration systems, which include purging gases in the culture vessel overlay space and gas exchanger, fulfil gaseous requirements without the need for direct sparging into the culture medium, ensuring stress-free cultivation of delicate cells while maintaining a high kLa in the bioreactor.

It is easier to perform downstream processing because there is no need for centrifugation or filtration because cells are immobilized in the dynamic-bed matrix during perfusion processing. With single-use sensors for pH, dissolved oxygen, temperature, glucose (optical), lactate (optical), and more, automatic control of culture conditions is smoothly integrated. In addressing the bottlenecks of large-scale stem cell culture technologies, CellBRx® bioreactors offer a unique advantage: the ability to recover healthy cells at a large scale using straightforward cell dissociation techniques.

We provide a comprehensive range of cell culture bioreactors featuring working volumes spanning from 15L to 200L. Our advanced DBR technology-based bioreactor systems are accessible for seed-train applications, process development, small- to pilot-scale production up to 5 L scale, and large-scale GMP manufacturing. Leveraging our global supply chain and stringent in-house quality control protocols, we deliver scalable, cost-effective, highly efficient, and fully customizable single-use bioreactors – CellBRx® to meet your unique needs.