The MiniBRx® 0.25 multi-bioreactors are high throughput, perfusion-enabled automated bioreactor systems for process development with up to 16 fully-featured single-use 100ml/250ml mini-scale bioreactors.
MiniBRx®0.25
This system integrates Ready-to-Plus and easily connects bioreactors with flexible and user-friendly software. It enables scientists to manage many more experiments at the same time while reducing the costs per experiment. Therefore, MiniBRx®0.25 is an accurate solutions, and it cost-effectively replicates bioreactor conditions. It can serve as a microscale model for a wide range of upstream processes, such as Perfusion clone selection, process characterization, and process optimization studies.
Highlights And Benefits
- SCADA-based Advanced Process Control System.
- 100ml/250ml mini-bioreactors with integrated TFF-based perfusion set-up.
- Up to 16 brx docking stations with fully loaded modular process analytics.
- Scale-down modeling and DOE/QbD experiments.
- Cell culture process development/characterization/optimization studies.
- High throughput perfusion-based process development.
- Microcarrier-based Adherent cell processing.
Process Control | Sensors
Sensor | Measurement | Display Accuracy
- Temperature: Pt100 | 0-150°C (temperature control 30-40°C) | 0.1°C
- Dissolved oxygen, single-use: Optical | 0-100 % | 0.1 %
- pH, single-use: Optical | 5.5 – 8.5 pH | 0.1 pH
- Level: Electrical conductive, SS, insulated (optional)
- pCO2: Optical | 8 – 180 mmHg pCO2 | 1.2 mmHg (optional)
- Glucose: Enzymatic sensor | 0 – 40 g/L | 0.01 g/L (optional)
- Lactate: Enzymatic sensor | 0 – 10 g/L | 0.01 g/L (optional)
- Biomass: Capacitance | 0-400 e6 cells/mL | 0.01 e6 cells/mL (optional)
- Load cells: Optional
- Pressure: Single-use | up to 75 psi (5.2 bar) | 2% or less (optional)
- Exhaust Gas Analyzer: Optional
Aeration Module
- Type of Sparger: Open Pipe / Ring/ Micro (sintered)
- Outlet to culture vessel: Hose barbs for tubing’s with Ø internal = 2.4 mm (0.09”)
- Module: Additive flow 4-gas (Air, O2, N2, CO2) aeration module
- Gas outlets: 2 nos : Sparger and Overlay
- Max. total flow: Up to 2 lpm per gassing line
- Gas switching valves sparge to o/L: Optional
- Mass flow controllers: Up to 5 / Brx
- Solenoid valves: Up to 6 / Brx
Agitation Module
- Max. stirrer speed: 800 RPM
- Motor (Overhead drive): Servo with Gearbox, magnetic coupling, Power: 100 W
- Impellers: 3-blade, Pitched blade Segmented, Customizable